Isonicotinic Acid Hydrazide Conversion to Isonicotinyl-NAD by Catalase-peroxidases

Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.

Activation of the pro-drug isoniazid (INH) as an anti-tubercular drug in Mycobacterium tuberculosis involves its conversion to isonicotinyl-NAD, a reaction that requires the catalase-peroxidase KatG. This report shows that the reaction proceeds in the absence of KatG at a slow rate in a mixture of INH, NAD(+), Mn(2+), and O(2), and that the inclusion of KatG increases the rate by >7 times. Supe...

Isonicotinic Acid Hydrazide (inh) Conversion to Isonicotinyl-nad by Catalase-peroxidases*

CATALASE-PEROXIDASES* Ben Wiseman, Xavier Carpena, Miguel Feliz, Lynda J. Donald, Miquel Pons, Ignacio Fita and Peter C. Loewen From Departments of Microbiology and Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2; Institute for Research in Biomedicine (IRB-Barcelona), and Institut de Biologia Molecular (IBMBCSIC), Parc Científic, Baldiri Reixac 10, 08028 Barcelona, Spain, and University...

Isonicotinic Acid Hydrazide

Pyridoxine-responsive anemia conditioned by isonicotinic acid hydrazide.

S INCE THE FIRST report in 1956 of a patient with pyridoxine-responsive anemia, a number of other patients have been reported.”2 The red blood cells usually are hypochromic and microcytic but occasionally they may be macrocytic and accompanied by megaboblastic bone marrow maturation. It is unlikely that many of these patients have a simple dietary deficiency of pyridoxine, since barge doses of ...

Carcinogenesis in Swiss mice by isonicotinic acid hydrazide.

There have been several demonstrations of the limited tumorigenicity of INH in mice. The 1st such experiment was re ported by Juhász et al. (3, 4), who reported the induction of pulmonary adenomas, lymphomas, and leukemia.s in randomly bred mice injected i.p. with INH. In a subsequent study these same investigators found only an induction in lymphomas and leukemias but reported the occurrence ...